Endocrine Abstracts

Hypertension or elevated arterial blood pressure (BP) is the most common cause of cardiovascular diseases (CVDs). The arterial BP is regulated by renin-angiotensin-aldosterone system (RAAS), whereas dysfunctional RAAS may lead to development of hypertension and associated CVDs. Parathyroid hormone (PTH) secreted by parathyroid glands regulates RAAS by directly stimulating aldosterone synthesis in zona glomerulosa cells, which leads to development of hypertension. Conversely, R...

Vitamin D plays a key role in the control of cardiovascular diseases (CVDs), acting as negative regulator of renin-angiotensin-aldosterone-system (RAAS), whereas calcium directly affects central blood pressure (BP) control center, nucleus tractus solitarus. We investigated associations between plasma concentrations of vitamin D and calcium and BP in 100 hypertensive CVDs patients and 100 normotensive subjects of 21–60 years. Vitamin D concentrations were measured using EC...